Effectors and Pathogenesis in Leptosphaeria maculans

EPLM

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The EPLM team studies the fungal pathogen Leptosphaeria maculans, responsible for crown necrosis in rapeseed (Brassica napus). We are developing multidisciplinary approaches to decipher the molecular dialogue between the interacting partners, its regulation, and its molecular evolution under the selection pressure exerted by resistance genes. We aim to propose sustainable strategies for the deployment of varietal resistance, in close interaction with socio-economic partners. We combine expertise in plant pathology, fungal genetics, genomics and epigenetics, fungal community studies and molecular biology, as well as complementary collaborations (genetics and plant breeding, biochemistry and structural biology). We have established the L. maculans/Brassica pathosystem as a model for the study of plant-fungus interactions, leading to new concepts such as (i) the “two-speed” genome paradigm; (ii) the consequences of genome structure on the expression of effector-encoding genes and on mechanisms of adaptation to plant resistance; and (iii) the emergence of complex mechanisms to escape recognition of the fungus by the plant's surveillance system.

2024 EPLM.jpg

Group leaders: Isabelle FUDAL, and Valérie LAVAL

dir-EPLM@inrae.fr

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Angélique GAUTIER, Valérie LAVAL and Marie-Hélène BALESDENT have developed a new tool, MPseqM, combining multiplex PCR and Illumina sequencing, to characterize the allelic variants of eight AvrLm genes in L. maculans populations. This work was the subject of an article published in BMC Microbiology.

Isabelle FUDAL and Audren JIQUEL presented their research work at the latest European Conference on Fungal Genetics (ECFG17), held in Dublin from March 2 to 5, 2025.

Since January 25, 2025, Anita VIENNET has joined the EPLM team.

Since September 1, 2024, Salomé SOULÉ and Jessy GRAVELINE have joined the EPLM team.

02 July 2024

Campus Agro Paris-Saclay, 22 place de l'Agronomie, 91120 Palaiseau. Amphi C2.0.37 (Bâtiment C2, rez-de-chaussée)

Julie NOAH's thesis defense

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Julie NOAH presented her thesis entitled "Identification of the determinants of the adaptation of Leptosphaeria maculans to different Brassica species", under the supervision of Jessica SOYER, on Tuesday July 2

A study published in the New Phytologist, carried out as part of Colin Clairet's PhD thesis under the supervision of Jessica Soyer and Isabelle Fudal at the BIOGER unit, characterized how the expression of effectors of a phytopathogenic fungus was controlled during infection of its host plant.